Genetic Mapping of a Maternal Locus Responsible for Familial Hydatidiform Moles
نویسندگان
چکیده
منابع مشابه
Genetic mapping of a maternal locus responsible for familial hydatidiform moles.
Hydatidiform mole (HM) is the product of an aberrant human pregnancy in which there is an abnormal embryonic development and proliferation of placental villi. The incidence of HM varies between ethnic groups, and occurs in 1 in every 1500 pregnancies in the USA. All HM cases are sporadic, except for extremely rare familial cases. The exact mechanisms leading to molar pregnancies are unknown. We...
متن کاملTetraploidy in hydatidiform moles.
STUDY QUESTION How does tetraploidy develop in hydatidiform moles (HMs), and what is the frequency of the different origins? SUMMARY ANSWER Most molar pregnancies with tetraploid cells appear to be produced by somatic endoreduplications, while a minority originate from a tetraploid zygote. The frequency of zygotic tetraploidy was estimated to be 0.7%. WHAT IS KNOWN ALREADY The parental orig...
متن کاملSex chromatin of hydatidiform moles.
The placenta is a homograft which is tolerated by the host for an unusually long time. The hydatidiform mole may be said to be even more successful in this respect for it can survive longer and penetrate further in the host even in the absence of a viable foetus. Recent observations that a large number of hydatidiform moles are chromatin positive are of much interest, but so far the reported se...
متن کاملNLRP7 and KHDC3L, the two maternal-effect proteins responsible for recurrent hydatidiform moles, co-localize to the oocyte cytoskeleton.
STUDY QUESTION What is the subcellular localization in human oocytes and preimplantation embryos, of the two maternal-effect proteins, NLRP7 and KHDC3L, responsible for recurrent hydatidiform moles (RHMs)? SUMMARY ANSWER NLRP7 and KHDC3L localize to the oocyte cytoskeleton and are polar and absent from the cell-to-cell contact region in early preimplantation embryos. WHAT IS KNOWN ALREADY N...
متن کاملGenetic refinement and physical mapping of a biparental complete hydatidiform mole locus on chromosome 19q13.4.
Hydatidiform mole (HM) is an uncommon type of pregnancy, typically resulting from a diandric conception. HM may be defined as complete (CHM), having an androgenetic, diploid genome (AnCHM), 2 or partial, having a diandric, triploid genome (PHM). 4 A rare type of CHM is diploid but, unlike AnCHM, is biparental (BiCHM) in origin. 6 It has been shown that AnCHM and BiCHM are pathologically indisti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 1999
ISSN: 0964-6906,1460-2083
DOI: 10.1093/hmg/8.4.667